Gene Symbol |
EREG
|
Entrez Gene |
2069
|
Alt Symbol |
ER
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
epiregulin
|
Other Description |
proepiregulin
|
Swissprots |
O14944 Q6FH69 B2RC66
|
Accessions |
EAX05709 O14944 AK314959 BAG37463 BC035806 BC136404 AAI36405 BC136405 AAI36406 CR541887 CAG46685 D30783 BAA22146 NM_001432 NP_001423
|
Function |
Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269|PubMed:9419975}.
|
Subcellular Location |
Epiregulin: Secreted, extracellular space.
|
Tissue Specificity |
In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
|
Top Pathways |
ErbB signaling pathway
|