Gene Symbol | EREG |
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Entrez Gene | 2069 |
Alt Symbol | ER |
Species | Human |
Gene Type | protein-coding |
Description | epiregulin |
Other Description | proepiregulin |
Swissprots | O14944 Q6FH69 B2RC66 |
Accessions | EAX05709 O14944 AK314959 BAG37463 BC035806 BC136404 AAI36405 BC136405 AAI36406 CR541887 CAG46685 D30783 BAA22146 NM_001432 NP_001423 |
Function | Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269|PubMed:9419975}. |
Subcellular Location | Epiregulin: Secreted, extracellular space. |
Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
Top Pathways | ErbB signaling pathway |
Epiregulin CRISPR/Cas9 KO Plasmid (h) - sc-404273 from Santa Cruz Biotechnology
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Epiregulin HDR Plasmid (h) - sc-404273-HDR from Santa Cruz Biotechnology
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Epiregulin Double Nickase Plasmid (h) - sc-404273-NIC from Santa Cruz Biotechnology
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Epiregulin Double Nickase Plasmid (h2) - sc-404273-NIC-2 from Santa Cruz Biotechnology
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Epiregulin CRISPR Activation Plasmid (h) - sc-404273-ACT from Santa Cruz Biotechnology
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Epiregulin CRISPR Activation Plasmid (h2) - sc-404273-ACT-2 from Santa Cruz Biotechnology
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Epiregulin Lentiviral Activation Particles (h) - sc-404273-LAC from Santa Cruz Biotechnology
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Epiregulin Lentiviral Activation Particles (h2) - sc-404273-LAC-2 from Santa Cruz Biotechnology
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Epiregulin siRNA (h) - sc-39418 from Santa Cruz Biotechnology
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Epiregulin shRNA Plasmid (h) - sc-39418-SH from Santa Cruz Biotechnology
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Epiregulin shRNA (h) Lentiviral Particles - sc-39418-V from Santa Cruz Biotechnology
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Epiregulin RNAi - H00002069-R01 from Novus Biologicals
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MISSION® esiRNA - EHU142821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7956 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7956 from Sigma-Aldrich
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EREG siRNA (Human) - CRH1444 from Cohesion Biosciences
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EREG - MBS8215306 from MyBioSource
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shRNA set against Human EREG (NM_001432.2) - SHH286977 from Creative biogene
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shRNA set against Human EREG(NM_001432.2) - SHH038459 from Creative biogene
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EREG shRNA Plasmid (Human) - CHH1444 from Cohesion Biosciences
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EREG miRNA 3'UTR clone - MiUTR1H-03292 from Creative biogene
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