Gene Symbol | EREG |
---|---|
Entrez Gene | 2069 |
Alt Symbol | ER |
Species | Human |
Gene Type | protein-coding |
Description | epiregulin |
Other Description | proepiregulin |
Swissprots | O14944 Q6FH69 B2RC66 |
Accessions | EAX05709 O14944 AK314959 BAG37463 BC035806 BC136404 AAI36405 BC136405 AAI36406 CR541887 CAG46685 D30783 BAA22146 NM_001432 NP_001423 |
Function | Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269|PubMed:9419975}. |
Subcellular Location | Epiregulin: Secreted, extracellular space. |
Tissue Specificity | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
Top Pathways | ErbB signaling pathway |