| Gene Symbol |
PRG4
|
| Entrez Gene |
10216
|
| Alt Symbol |
CACP, HAPO, JCAP, MSF, SZP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteoglycan 4
|
| Other Description |
articular superficial zone protein|hemangiopoietin|lubricin|megakaryocyte stimulating factor|superficial zone proteoglycan
|
| Swissprots |
Q9BX49 Q6DNC5 Q92954 Q6ZMZ5 Q6DNC4
|
| Accessions |
EAW91201 EAW91202 Q92954 AK057197 BAG51882 AK131434 BAD18580 AK297718 BAH12654 AK301343 BAG62891 AK301487 BAH13495 AK308235 AY653037 AAT74745 AY653038 AAT74746 CA435357 DA977744 DA995681 DC295855 DC404857 U70136 AAB09089 NM_001127708 NP_001121180 NM_001127709 NP_001121181 NM_001127710 NP_001121182 NM_001303232 NP_001290161 NM_005807 NP_005798
|
| Function |
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:14976050}.
|
| Tissue Specificity |
Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. {ECO:0000269|PubMed:10545950, ECO:0000269|PubMed:11124536}.
|