| Gene Symbol | PRG4 |
|---|---|
| Entrez Gene | 10216 |
| Alt Symbol | CACP, HAPO, JCAP, MSF, SZP |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteoglycan 4 |
| Other Description | articular superficial zone protein|hemangiopoietin|lubricin|megakaryocyte stimulating factor|superficial zone proteoglycan |
| Swissprots | Q9BX49 Q6DNC5 Q92954 Q6ZMZ5 Q6DNC4 |
| Accessions | EAW91201 EAW91202 Q92954 AK057197 BAG51882 AK131434 BAD18580 AK297718 BAH12654 AK301343 BAG62891 AK301487 BAH13495 AK308235 AY653037 AAT74745 AY653038 AAT74746 CA435357 DA977744 DA995681 DC295855 DC404857 U70136 AAB09089 NM_001127708 NP_001121180 NM_001127709 NP_001121181 NM_001127710 NP_001121182 NM_001303232 NP_001290161 NM_005807 NP_005798 |
| Function | Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:14976050}. |
| Tissue Specificity | Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed. {ECO:0000269|PubMed:10545950, ECO:0000269|PubMed:11124536}. |
Human PRG4 cDNA clone(NM_001127708.1) - CDFH015070 from Creative Biomart
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Human PRG4 cDNA clone(NM_001127709.1) - CDFH015071 from Creative Biomart
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Human PRG4 cDNA clone(NM_001127710.1) - CDFH015072 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127708.1) - CDCR348886 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127708.1) - CDCR348887 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127709.1) - CDCR348888 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127709.1) - CDCR348890 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127710.1) - CDCR348891 from Creative Biomart
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Human PRG4 ORF Clone(NM_001127710.1) - CDCR348897 from Creative Biomart
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human PRG4 ORF clone (NM_005807.3) - CDCH067638 from Creative biogene
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human PRG4 ORF clone (NM_001127710.1) - CDCH067640 from Creative biogene
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human PRG4 ORF clone (NM_001127709.1) - CDCH067642 from Creative biogene
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human PRG4 ORF clone (NM_001127708.1) - CDCH067644 from Creative biogene
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Human PRG4 cDNA Clone(NM_001127708.1) - CDFH015070 from Creative biogene
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Human PRG4 cDNA Clone(NM_001127709.1) - CDFH015071 from Creative biogene
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Human PRG4 cDNA Clone(NM_001127710.1) - CDFH015072 from Creative biogene
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