| Gene Symbol |
LIN7C
|
| Entrez Gene |
55327
|
| Alt Symbol |
LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lin-7 homolog C (C. elegans)
|
| Other Description |
LIN-7 protein 3|mammalian lin-seven protein 3|protein lin-7 homolog C|veli-3|vertebrate lin-7 homolog 3
|
| Swissprots |
Q9NUP9
|
| Accessions |
EAW68282 EAW68283 Q9NUP9 AF090900 AAF24024 AK002077 BAA92072 AK025540 AK223156 BAD96876 AL833601 BC009774 BC039459 BC053907 AAH53907 DA231006 NM_018362 NP_060832
|
| Function |
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.
|
![Western Blot: LIN7C Overexpression Lysate (Adult Normal) [NBP2-06816] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LIN7C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1581_LIN7C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06816-img0001.jpg)