LIN7C

Gene Symbol LIN7C
Entrez Gene 55327
Alt Symbol LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3
Species Human
Gene Type protein-coding
Description lin-7 homolog C (C. elegans)
Other Description LIN-7 protein 3|mammalian lin-seven protein 3|protein lin-7 homolog C|veli-3|vertebrate lin-7 homolog 3
Swissprots Q9NUP9
Accessions EAW68282 EAW68283 Q9NUP9 AF090900 AAF24024 AK002077 BAA92072 AK025540 AK223156 BAD96876 AL833601 BC009774 BC039459 BC053907 AAH53907 DA231006 NM_018362 NP_060832
Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Veli3 CRISPR/Cas9 KO Plasmid (h) - sc-412521 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 HDR Plasmid (h) - sc-412521-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 Double Nickase Plasmid (h) - sc-412521-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 Double Nickase Plasmid (h2) - sc-412521-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 CRISPR Activation Plasmid (h) - sc-412521-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 CRISPR Activation Plasmid (h2) - sc-412521-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 Lentiviral Activation Particles (h) - sc-412521-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 Lentiviral Activation Particles (h2) - sc-412521-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Veli3 siRNA (h) - sc-42320 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Veli3 shRNA Plasmid (h) - sc-42320-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Veli3 shRNA (h) Lentiviral Particles - sc-42320-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU061441 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11735 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11735 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LIN7C siRNA (Human) - CRJ0659 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LIN7C (NM_018362.3) - SHH330551 from Creative biogene

Category siRNA
Species Reactivities Human

LIN7C shRNA Plasmid (Human) - CHJ0659 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LIN7C miRNA 3'UTR clone - MiUTR4H-TG05072 from Creative biogene

Species Reactivities Human
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