| Gene Symbol |
PLA1A
|
| Entrez Gene |
51365
|
| Alt Symbol |
PS-PLA1, PSPLA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A1 member A
|
| Other Description |
phosphatidylserine-specific phospholipase A1alpha
|
| Swissprots |
B2R8V2 B4DXA2 Q53H76 O95991 Q9UPD2 Q86WX6
|
| Accessions |
EAW79557 EAW79558 EAW79559 EAW79560 Q53H76 AF035268 AAC98921 AF035269 AAC98922 AK222705 BAD96425 AK301880 BAG63314 AK313519 BAG36299 BC035347 BC047703 AAH47703 BE221465 BX647516 DB189568 DB255030 HQ448617 ADQ33095 U37591 AAC99994 XM_006713653 XP_006713716 NM_001206960 NP_001193889 NM_001206961 NP_001193890 NM_015900 NP_056984 NM_001293225 NP_001280154 NR_120610
|
| Function |
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. {ECO:0000269|PubMed:10196188}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney. {ECO:0000269|PubMed:9074642}.
|