Gene Symbol | PLA1A |
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Entrez Gene | 51365 |
Alt Symbol | PS-PLA1, PSPLA1 |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A1 member A |
Other Description | phosphatidylserine-specific phospholipase A1alpha |
Swissprots | B2R8V2 B4DXA2 Q53H76 O95991 Q9UPD2 Q86WX6 |
Accessions | EAW79557 EAW79558 EAW79559 EAW79560 Q53H76 AF035268 AAC98921 AF035269 AAC98922 AK222705 BAD96425 AK301880 BAG63314 AK313519 BAG36299 BC035347 BC047703 AAH47703 BE221465 BX647516 DB189568 DB255030 HQ448617 ADQ33095 U37591 AAC99994 XM_006713653 XP_006713716 NM_001206960 NP_001193889 NM_001206961 NP_001193890 NM_015900 NP_056984 NM_001293225 NP_001280154 NR_120610 |
Function | Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. {ECO:0000269|PubMed:10196188}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney. {ECO:0000269|PubMed:9074642}. |
Human PLA1A full length protein - ab162524 from Abcam
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Human PLA1A full length protein - ab180288 from Abcam
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Human PLA1A protein fragment - ab162525 from Abcam
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PSPLA1 / Phospholipase A1 Antibody Blocking Peptide - LS-E31345 from LifeSpan Bioscience
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PSPLA1 / Phospholipase A1 Antibody Blocking Peptide - LS-E10188 from LifeSpan Bioscience
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PLA1A Partial Recombinant Protein - H00051365-Q01 from Novus Biologicals
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PLA1A Recombinant Protein - H00051365-P01 from Novus Biologicals
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PLA1A-Antibody-Center-Blocking-Peptide - BP9548c from Abgent, a WuXi AppTec company
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PLA1A Blocking Peptide - 33R-9022 from Fitzgerald
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PLA1A protein (His tag) - 80R-3794 from Fitzgerald
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Human Phospholipase A1 Protein - abx068526 from Abbexa
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Human Phospholipase A1 Protein - abx068525 from Abbexa
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PLA1A (26-456, His-tag) - AR51481PU-N from Acris Antibodies
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PLA1A (26-456, His-tag) - AR51481PU-S from Acris Antibodies
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PLA1A - H00051365-P01 from Acris Antibodies
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PLA1A - H00051365-Q01-10 from Acris Antibodies
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PLA1A - H00051365-Q01-25 from Acris Antibodies
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PLA1A (C-term) Control Peptide - AP55465CP-N from Acris Antibodies
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Phospholipase A1 (PLA1), Human - 20-7497 from ARP American Research Products
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Phospholipase A1 (PLA1), Human - 20-7498 from ARP American Research Products
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PLA1A, 26-456aa, Human, His tag, E.coli - 01-P2661 from ARP American Research Products
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PLA1A Peptide - 7059P from ProSci
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PLA1A fusion protein - ag5467 from Proteintech Group
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Recombinant Human PLA1A, His-tagged - PLA1A-168H from Creative Biomart
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Recombinant Phospholipase A1 (PLA1) - RPB151Hu01 from Uscn Life Science Inc.
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