| Gene Symbol |
PPP1R3B
|
| Entrez Gene |
79660
|
| Alt Symbol |
GL, PPP1R4, PTG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 3B
|
| Other Description |
PP1 subunit R4|hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL|hepatic glycogen-targeting subunit, G(L)|protein phosphatase 1 regulatory subunit 3B|protein phosphatase 1 regulatory subunit 4|protein phosphatase 1, regulatory (inhibitor) subunit 3B
|
| Swissprots |
B3KTV3 Q86XI6 Q9H812
|
| Accessions |
CAC69382 EAW65572 Q86XI6 AI078688 AI263711 AK024067 BAB14811 AK091994 AK096119 BAG53215 BC043388 AAH43388 BQ431880 DA100998 DB282578 HQ448647 ADQ33125 XM_006716253 XP_006716316 XM_011543836 XP_011542138 NM_001201329 NP_001188258 NM_024607 NP_078883
|
| Function |
Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung. {ECO:0000269|PubMed:11872655, ECO:0000269|PubMed:17555403}.
|
| Top Pathways |
Insulin signaling pathway
|