PPP1R3B
| Gene Symbol | PPP1R3B |
|---|---|
| Entrez Gene | 79660 |
| Alt Symbol | GL, PPP1R4, PTG |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, regulatory subunit 3B |
| Other Description | PP1 subunit R4|hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL|hepatic glycogen-targeting subunit, G(L)|protein phosphatase 1 regulatory subunit 3B|protein phosphatase 1 regulatory subunit 4|protein phosphatase 1, regulatory (inhibitor) subunit 3B |
| Swissprots | B3KTV3 Q86XI6 Q9H812 |
| Accessions | CAC69382 EAW65572 Q86XI6 AI078688 AI263711 AK024067 BAB14811 AK091994 AK096119 BAG53215 BC043388 AAH43388 BQ431880 DA100998 DB282578 HQ448647 ADQ33125 XM_006716253 XP_006716316 XM_011543836 XP_011542138 NM_001201329 NP_001188258 NM_024607 NP_078883 |
| Function | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung. {ECO:0000269|PubMed:11872655, ECO:0000269|PubMed:17555403}. |
| Top Pathways | Insulin signaling pathway |
PPP1R4 CRISPR/Cas9 KO Plasmid (h) - sc-418330 from Santa Cruz Biotechnology
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PPP1R4 HDR Plasmid (h) - sc-418330-HDR from Santa Cruz Biotechnology
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PPP1R4 Double Nickase Plasmid (h) - sc-418330-NIC from Santa Cruz Biotechnology
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PPP1R4 Double Nickase Plasmid (h2) - sc-418330-NIC-2 from Santa Cruz Biotechnology
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PPP1R4 CRISPR Activation Plasmid (h) - sc-418330-ACT from Santa Cruz Biotechnology
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PPP1R4 CRISPR Activation Plasmid (h2) - sc-418330-ACT-2 from Santa Cruz Biotechnology
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PPP1R4 Lentiviral Activation Particles (h) - sc-418330-LAC from Santa Cruz Biotechnology
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PPP1R4 Lentiviral Activation Particles (h2) - sc-418330-LAC-2 from Santa Cruz Biotechnology
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PPP1R4 siRNA (h) - sc-77814 from Santa Cruz Biotechnology
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PPP1R4 shRNA Plasmid (h) - sc-77814-SH from Santa Cruz Biotechnology
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PPP1R4 shRNA (h) Lentiviral Particles - sc-77814-V from Santa Cruz Biotechnology
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PPP1R3B RNAi - H00079660-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036341 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0578 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0579 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0577 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17279 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17279 from Sigma-Aldrich
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PPP1R3B siRNA (Human) - CRJ2465 from Cohesion Biosciences
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shRNA set against Human PPP1R3B (NM_024607.3) - SHH381224 from Creative biogene
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PPP1R3B shRNA Plasmid (Human) - CHJ2465 from Cohesion Biosciences
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PPP1R3B miRNA 3'UTR clone - MiUTR4H-TG06948 from Creative biogene
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