| Gene Symbol |
RASSF6
|
| Entrez Gene |
166824
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras association (RalGDS/AF-6) domain family member 6
|
| Other Description |
Ras association (RalGDS/AF-6) domain family 6|putative RAS binding protein|ras association domain-containing protein 6
|
| Swissprots |
Q86WG9 Q6PDA6 Q86WH0 Q6ZTQ3 Q68DT2
|
| Accessions |
EAX05685 EAX05686 Q6ZTQ3 AI579909 AK002032 AK126346 BAC86530 AW070877 AW407403 AY217664 AAO61689 AY217665 AAO61690 BC058835 AAH58835 BM923326 BU959014 BX424428 BX957171 CR749283 CAH18138 XM_011531687 XP_011529989 XM_011531688 XP_011529990 XM_011531689 XP_011529991 XM_011531690 XP_011529992 XM_011531691 XP_011529993 XR_938698 NM_001270391 NP_001257320 NM_001270392 NP_001257321 NM_177532 NP_803876 NM_201431 NP_958834
|
| Function |
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. {ECO:0000269|PubMed:17404571}.
|
| Top Pathways |
Hippo signaling pathway
|