Gene Symbol | RASSF6 |
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Entrez Gene | 166824 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | Ras association (RalGDS/AF-6) domain family member 6 |
Other Description | Ras association (RalGDS/AF-6) domain family 6|putative RAS binding protein|ras association domain-containing protein 6 |
Swissprots | Q86WG9 Q6PDA6 Q86WH0 Q6ZTQ3 Q68DT2 |
Accessions | EAX05685 EAX05686 Q6ZTQ3 AI579909 AK002032 AK126346 BAC86530 AW070877 AW407403 AY217664 AAO61689 AY217665 AAO61690 BC058835 AAH58835 BM923326 BU959014 BX424428 BX957171 CR749283 CAH18138 XM_011531687 XP_011529989 XM_011531688 XP_011529990 XM_011531689 XP_011529991 XM_011531690 XP_011529992 XM_011531691 XP_011529993 XR_938698 NM_001270391 NP_001257320 NM_001270392 NP_001257321 NM_177532 NP_803876 NM_201431 NP_958834 |
Function | Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250}. |
Tissue Specificity | Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. {ECO:0000269|PubMed:17404571}. |
Top Pathways | Hippo signaling pathway |
RASSF6 CRISPR/Cas9 KO Plasmid (h) - sc-409542 from Santa Cruz Biotechnology
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RASSF6 HDR Plasmid (h) - sc-409542-HDR from Santa Cruz Biotechnology
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RASSF6 Double Nickase Plasmid (h) - sc-409542-NIC from Santa Cruz Biotechnology
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RASSF6 Double Nickase Plasmid (h2) - sc-409542-NIC-2 from Santa Cruz Biotechnology
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RASSF6 CRISPR Activation Plasmid (h) - sc-409542-ACT from Santa Cruz Biotechnology
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RASSF6 CRISPR Activation Plasmid (h2) - sc-409542-ACT-2 from Santa Cruz Biotechnology
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RASSF6 Lentiviral Activation Particles (h) - sc-409542-LAC from Santa Cruz Biotechnology
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RASSF6 Lentiviral Activation Particles (h2) - sc-409542-LAC-2 from Santa Cruz Biotechnology
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RASSF6 siRNA (h) - sc-89270 from Santa Cruz Biotechnology
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RASSF6 shRNA Plasmid (h) - sc-89270-SH from Santa Cruz Biotechnology
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RASSF6 shRNA (h) Lentiviral Particles - sc-89270-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18000 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18000 from Sigma-Aldrich
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RASSF6 siRNA (Human) - CRJ6049 from Cohesion Biosciences
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RASSF6 - MBS8201207 from MyBioSource
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shRNA set against Human RASSF6 (NM_177532.4) - SHH390212 from Creative biogene
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Human RASSF6 siRNA - orb276550 from Biorbyt
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RASSF6 shRNA Plasmid (Human) - CHJ6049 from Cohesion Biosciences
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RASSF6 miRNA 3'UTR clone - MiUTR4H-TG12297 from Creative biogene
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