| Gene Symbol |
STK10
|
| Entrez Gene |
6793
|
| Alt Symbol |
LOK, PRO2729
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/threonine kinase 10
|
| Other Description |
lymphocyte-oriented kinase|serine/threonine-protein kinase 10
|
| Swissprots |
Q6NSK0 A6ND35 O94804 B3KMY1 B2R8F5 Q9UIW4
|
| Accessions |
EAW61439 O94804 AB015718 BAA35073 AF119894 AAF69648 AI584023 AK022960 BAG51143 AK092814 AK307943 AK313350 BAG36152 AL133081 CAB61400 BC014413 BC070077 AAH70077 BI459912 DA507768 DB068209 XM_011534641 XP_011532943 XM_011534642 XP_011532944 XM_011534643 XP_011532945 XM_011534644 XP_011532946 NM_005990 NP_005981
|
| Function |
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}.
|
| Tissue Specificity |
Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269|PubMed:12639966}.
|