Gene Symbol | STK10 |
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Entrez Gene | 6793 |
Alt Symbol | LOK, PRO2729 |
Species | Human |
Gene Type | protein-coding |
Description | serine/threonine kinase 10 |
Other Description | lymphocyte-oriented kinase|serine/threonine-protein kinase 10 |
Swissprots | Q6NSK0 A6ND35 O94804 B3KMY1 B2R8F5 Q9UIW4 |
Accessions | EAW61439 O94804 AB015718 BAA35073 AF119894 AAF69648 AI584023 AK022960 BAG51143 AK092814 AK307943 AK313350 BAG36152 AL133081 CAB61400 BC014413 BC070077 AAH70077 BI459912 DA507768 DB068209 XM_011534641 XP_011532943 XM_011534642 XP_011532944 XM_011534643 XP_011532945 XM_011534644 XP_011532946 NM_005990 NP_005981 |
Function | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}. |
Tissue Specificity | Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269|PubMed:12639966}. |
Active human LOK protein fragment - ab55710 from Abcam
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Human LOK protein fragment - ab131984 from Abcam
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Human LOK protein fragment - ab159607 from Abcam
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STK10 / LOK Antibody Blocking Peptide - LS-E3455 from LifeSpan Bioscience
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STK10 / LOK Antibody Blocking Peptide - LS-E27854 from LifeSpan Bioscience
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STK10 / LOK Antibody Blocking Peptide - LS-E9393 from LifeSpan Bioscience
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Recombinant Human LOK Protein - H00006793-P01 from Novus Biologicals
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Recombinant Human LOK Protein - H00006793-Q01 from Novus Biologicals
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LOK-Antibody-C-term-E707-Blocking-Peptide - BP7959b from Abgent, a WuXi AppTec company
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Human STK10 His tag protein - orb83829 from Biorbyt
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STK10 peptide - orb217984 from Biorbyt
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LOK Blocking Peptide - abx063315 from Abbexa
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STK10 / LOK - H00006793-P01-10 from Acris Antibodies
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STK10 / LOK - H00006793-P01-25 from Acris Antibodies
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STK10 / LOK - H00006793-Q01-10 from Acris Antibodies
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STK10 / LOK - H00006793-Q01-25 from Acris Antibodies
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STK10 / LOK - P5578 from Acris Antibodies
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STK10 fusion protein - ag1607 from Proteintech Group
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STK10 fusion protein - Ag22169 from Proteintech Group
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Lok1/Stk10, Active Human Recombinant Protein - GWB-88ED64 from Genway Biotech
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Recombinant Human Serine/Threonine Kinase 10, GST-tagged, Active - STK10-343H from Creative Biomart
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Recombinant Human STK10, His tagged - STK10-765H from Creative Biomart
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Recombinant Human Serine/Threonine Kinase 10, His-tagged - STK10-555H from Creative Biomart
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LOK Protein, active, 250 µg - 14-686M from EMD Millipore
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LOK Blocking Peptide - CBP2121 from Cohesion Biosciences
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