SRGAP3

Gene Symbol SRGAP3
Entrez Gene 9901
Alt Symbol ARHGAP14, MEGAP, SRGAP2, WRP
Species Human
Gene Type protein-coding
Description SLIT-ROBO Rho GTPase activating protein 3
Other Description SLIT-ROBO Rho GTPase activating protein 2|SLIT-ROBO Rho GTPase-activating protein 3|WAVE-associated Rac GTPase activating protein|mental disorder-associated GAP|rho GTPase-activating protein 14
Swissprots Q8IX13 Q8IZV8 O43295
Accessions EAW63950 EAW63951 O43295 AB007871 BAA24841 AB032982 BAA86470 AF427144 AAN07095 AF464189 AAN57784 AK054831 AK094355 AK126331 AU120948 BC039300 AAH39300 BC140004 BC172359 AAI72359 BM976179 DA532895 HG495444 HG495445 HG495446 HG495447 HG495448 XM_011534295 XP_011532597 XM_011534296 XP_011532598 XM_011534297 XP_011532599 XM_011534298 XP_011532600 XM_011534299 XP_011532601 XM_011534300 XP_011532602 XM_011534301 XP_011532603 XM_011534302 XP_011532604 XM_011534303 XP_011532605 XR_427300 NM_001033116 NM_001033117 NP_001028289 NM_014850 NP_055665
Function GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
Tissue Specificity Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
Top Pathways Axon guidance

WRP (B-3) - sc-514179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WRP (B-3): sc-514179. Western blot analysis of WRP expression in SH-SY5Y (A), IMR-32 (B) and Caki-1 (C) whole cell lysates.

WRP (E-11) - sc-374503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
WRP (E-11): sc-374503. Western blot analysis of WRP expression in mouse brain tissue extract.

WRP (H-150) - sc-134955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
WRP (H-150): sc-134955. Western blot analysis of WRP expression in non-transfected: sc-117752 (A) and human WRP transfected: sc-372331 (B) 293T whole cell lysates.

WRP (T-12) - sc-83491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

WRP (S-16) - sc-83490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WRP (S-16): sc-83490. Western blot analysis of WRP expression in non-transfected: sc-117752 (A) and human WRP transfected: sc-372331 (B) 293T whole cell lysates.

Anti-srGAP3 antibody - C-terminal - ab200087 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-srGAP3 antibody - C-terminal (ab200087) at 1/1000 dilutionLane 1 : Total cell extracts from HeLaLane 2 : Total cell extracts from Jurkat

Anti-SRGAP3 Antibody (aa213-262) - LS-C186764 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human A549. SRGAP3 antibody dilution 1.0 ug/ml.

SRGAP3 Antibody - NBP2-38521 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SRGAP3 Antibody [NBP2-38521] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

srGAP3 Polyclonal Antibody - bs-3660R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP3 antibody produced in rabbit - SAB4200050 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Tissue and cell lysates were separated on SDS-PAGE, blotted with 1.5 μg/mL Anti-SRGAP3 (<B>Cat. No. SAB4200050</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Mouse brain (S1 fraction)<BR/>2. HEK-293T overexpressing human SRGAP3A<BR/>3. HEK-293T overexpressing human SRGAP3B<BR/>4. HEK-293T non transfected<BR/>5. Mouse brain (S1 fraction) + SRGAP3 immunizing peptide (human, 897-915)

Anti-SRGAP3 antibody produced in rabbit - HPA036959 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SRGAP3: <B>Cat. No. HPA036959</B>: Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells.

Anti-SRGAP3 (C-terminal) antibody produced in rabbit - S1575 from Sigma-Aldrich

Prices $57.50, $332.50
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Rat brain (Lanes 1,4) and cell lysates of HEK-293T overexpressing human SRGAP3 (Lane 2) and of HEK-293T non transfected (Lane 3), were separated on SDS-PAGE, blotted with Anti-SRGAP3 (C-terminal) (<B>Cat. No. S1575</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody: 1 μg/mL<BR/>2. Antibody: 1 μg/mL<BR/>3. Antibody: 1 μg/mL<BR/>4. Antibody: 1 μg/mL + SRGAP3 immunizing peptide (human, 1082-1099)

SRGAP3 Polyclonal Antibody - A4354 from ABclonal

Prices $220.00, $380.00
Sizes 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cells, using SRGAP3 antibody.

Rabbit Anti-srGAP3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-3660R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-3660R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-3660R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-3660R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, Cy3 Conjugated - bs-3660R-Cy3 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, Cy5 Conjugated - bs-3660R-Cy5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, Cy5.5 Conjugated - bs-3660R-Cy5.5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, Cy7 Conjugated - bs-3660R-Cy7 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, FITC Conjugated - bs-3660R-FITC from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, Biotin Conjugated - bs-3660R-Biotin from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-srGAP3 Polyclonal Antibody, HRP Conjugated - bs-3660R-HRP from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Slit-Robo Rho Gtpase Activating Protein 3 Antibody - abx115594 from Abbexa

Host Rabbit
Clonality Polyclonal
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