| Gene Symbol |
SRGAP3
|
| Entrez Gene |
9901
|
| Alt Symbol |
ARHGAP14, MEGAP, SRGAP2, WRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLIT-ROBO Rho GTPase activating protein 3
|
| Other Description |
SLIT-ROBO Rho GTPase activating protein 2|SLIT-ROBO Rho GTPase-activating protein 3|WAVE-associated Rac GTPase activating protein|mental disorder-associated GAP|rho GTPase-activating protein 14
|
| Swissprots |
Q8IX13 Q8IZV8 O43295
|
| Accessions |
EAW63950 EAW63951 O43295 AB007871 BAA24841 AB032982 BAA86470 AF427144 AAN07095 AF464189 AAN57784 AK054831 AK094355 AK126331 AU120948 BC039300 AAH39300 BC140004 BC172359 AAI72359 BM976179 DA532895 HG495444 HG495445 HG495446 HG495447 HG495448 XM_011534295 XP_011532597 XM_011534296 XP_011532598 XM_011534297 XP_011532599 XM_011534298 XP_011532600 XM_011534299 XP_011532601 XM_011534300 XP_011532602 XM_011534301 XP_011532603 XM_011534302 XP_011532604 XM_011534303 XP_011532605 XR_427300 NM_001033116 NM_001033117 NP_001028289 NM_014850 NP_055665
|
| Function |
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
|
| Tissue Specificity |
Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
|
| Top Pathways |
Axon guidance
|