| Gene Symbol | SNX9 |
|---|---|
| Entrez Gene | 51429 |
| Alt Symbol | SDP1, SH3PX1, SH3PXD3A, WISP |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorting nexin 9 |
| Other Description | SH3 and PX domain-containing protein 1|SH3 and PX domain-containing protein 3A|Wiskott-Aldrich syndrome protein (WASP) interactor protein|sorting nexin-9 |
| Swissprots | Q9UJH6 Q9BVM1 Q9UP20 Q9BSI7 Q9Y5X1 |
| Accessions | EAW47668 EAW47669 Q9Y5X1 AB209736 BAD92973 AF001629 AAD00898 AF076957 AAD43001 AF121859 AAD27832 AF131214 AAF04473 AF172847 AAL54871 AF190158 AAQ13702 AJ420452 AJ420512 AK026637 AK127345 BAG54490 AK314360 BAG36992 BC001084 AAH01084 BC005022 AAH05022 BG766499 DA315945 DA336311 DQ893300 ABM84226 DQ896789 ABM87788 XM_005267015 XP_005267072 XM_011535886 XP_011534188 NM_016224 NP_057308 |
| Function | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO: |
| Subcellular Location | Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane. |
| Tissue Specificity | Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:10531379}. |