SNX9

Gene Symbol	SNX9
Entrez Gene	51429
Alt Symbol	SDP1, SH3PX1, SH3PXD3A, WISP
Species	Human
Gene Type	protein-coding
Description	sorting nexin 9
Other Description	SH3 and PX domain-containing protein 1|SH3 and PX domain-containing protein 3A|Wiskott-Aldrich syndrome protein (WASP) interactor protein|sorting nexin-9
Swissprots	Q9UJH6 Q9BVM1 Q9UP20 Q9BSI7 Q9Y5X1
Accessions	EAW47668 EAW47669 Q9Y5X1 AB209736 BAD92973 AF001629 AAD00898 AF076957 AAD43001 AF121859 AAD27832 AF131214 AAF04473 AF172847 AAL54871 AF190158 AAQ13702 AJ420452 AJ420512 AK026637 AK127345 BAG54490 AK314360 BAG36992 BC001084 AAH01084 BC005022 AAH05022 BG766499 DA315945 DA336311 DQ893300 ABM84226 DQ896789 ABM87788 XM_005267015 XP_005267072 XM_011535886 XP_011534188 NM_016224 NP_057308
Function	Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:
Subcellular Location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
Tissue Specificity	Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:10531379}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH3PX1 full length protein - ab178483 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human SH3PX1 full length protein - ab162548 from Abcam Category Protein Source Wheat germ Species Human

Human SH3PX1 peptide - ab87819 from Abcam Category Peptide

Human SH3PX1 peptide - ab23266 from Abcam Category Peptide Species Human

SH3PX1 peptide (510-522) - ab45878 from Abcam Category Peptide Species Human

SNX9 / WISP Antibody Blocking Peptide - LS-E26054 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SH3PX1 Protein - H00051429-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SNX9 blocking peptide - GTX89388-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

Human SNX9 Protein - abx060060 from Abbexa Category Protein Source Yeast Species Human

SH3PX1 Peptide - AC21-0882-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Sorting nexin-9 (SNX9) - H00051429-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

SNX9 Peptide - 46-407P from ProSci Category Peptide Species Human

SNX9 fusion protein - ag8440 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SNX9 fusion protein - Ag8446 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Sorting Nexin 9 (SNX9) - RPE879Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Sorting nexin-9(SNX9) - CSB-YP896917HU CSB-EP896917HU CSB-BP896917HU CSB-MP896917HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Sorting Nexin 9 Protein (Recombinant) - abx166761 from Abbexa Category Protein Source Human Species Human

Sorting nexin-9 (SNX9) - TP302822 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SNX9, Peptide - MBS426263 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog

SH3PX1 Recombinant Protein Antigen - NBP1-80777PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SNX9 Peptide, Human - M34GP14870H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Sorting Nexin 9 (SNX9) - RPU52262 from Biomatik Category Protein Prices $185.00, $378.00, $578.00, $688.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

SNX9 Recombinant Protein (OPCD07094) - OPCD07094 from Aviva Systems Biology Category Protein Source E.coli Species Human

SH3PX1 Recombinant Protein Antigen - NBP2-58144PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Sorting Nexin 9, Recombinant Protein - MBS2031351 from MyBioSource Category Protein Prices $185.00, $380.00, $585.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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