SNX9

Gene Symbol	SNX9
Entrez Gene	51429
Alt Symbol	SDP1, SH3PX1, SH3PXD3A, WISP
Species	Human
Gene Type	protein-coding
Description	sorting nexin 9
Other Description	SH3 and PX domain-containing protein 1|SH3 and PX domain-containing protein 3A|Wiskott-Aldrich syndrome protein (WASP) interactor protein|sorting nexin-9
Swissprots	Q9UJH6 Q9BVM1 Q9UP20 Q9BSI7 Q9Y5X1
Accessions	EAW47668 EAW47669 Q9Y5X1 AB209736 BAD92973 AF001629 AAD00898 AF076957 AAD43001 AF121859 AAD27832 AF131214 AAF04473 AF172847 AAL54871 AF190158 AAQ13702 AJ420452 AJ420512 AK026637 AK127345 BAG54490 AK314360 BAG36992 BC001084 AAH01084 BC005022 AAH05022 BG766499 DA315945 DA336311 DQ893300 ABM84226 DQ896789 ABM87788 XM_005267015 XP_005267072 XM_011535886 XP_011534188 NM_016224 NP_057308
Function	Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:
Subcellular Location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
Tissue Specificity	Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:10531379}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX9 (G-5) - sc-166863 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SNX9 (H-46) - sc-99027 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SNX9 (N-20) - sc-49143 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX9 (Y-20) - sc-49145 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX9 (S-20) - sc-49144 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SH3PX1 antibody - ab45866 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SH3PX1 antibody - ab125906 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-SH3PX1 antibody - ab15709 from Abcam Prices $0.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SH3PX1 antibody [2F1] - ab118996 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2F1

Anti-SH3PX1 antibody [EPR14399] - ab181856 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14399

Anti-SNX9 / WISP Antibody (clone 2F1) - LS-C115324 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2F1

Anti-SNX9 / WISP Antibody - LS-C335116 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX9 / WISP Antibody (clone 2A6) - LS-C115320 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2A6

Anti-SNX9 / WISP Antibody (clone 2A11) - LS-C115321 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2A11

Anti-SNX9 / WISP Antibody (clone 2E1) - LS-C115323 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2E1

Anti-SNX9 / WISP Antibody (clone 2G4) - LS-C115348 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2G4

Anti-SNX9 / WISP Antibody (clone 1B5) - LS-C115269 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1B5

Anti-SNX9 / WISP Antibody (clone 1E4) - LS-C115270 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E4

Anti-SNX9 / WISP Antibody (aa510-522) - LS-C55506 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SNX9 / WISP Antibody - LS-C192301 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

SH3PX1 Antibody (1B5) - NBP2-02609 from Novus Biologicals Prices $449.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1B5

SH3PX1 Antibody - NBP1-80777 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SH3PX1 Antibody - NB100-2813 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

SH3PX1 Antibody - NBP2-20348 from Novus Biologicals Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SH3PX1 Antibody - H00051429-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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