| Gene Symbol |
LRP6
|
| Entrez Gene |
4040
|
| Alt Symbol |
ADCAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 6
|
| Other Description |
LRP-6|low-density lipoprotein receptor-related protein 6
|
| Swissprots |
O75581 Q17RZ2
|
| Accessions |
AAD21410 CCF76957 CDM49020 EAW96253 O75581 AA126261 AB209683 BAD92920 AF074264 AAC33006 AK074543 BAG51971 AK074902 BAG52027 AK094666 AK124760 BC029941 BC117136 AAI17137 BC126405 AAI26406 BC143725 AAI43726 BP229563 XM_006719078 XP_006719141 XM_011520671 XP_011518973 XM_011548873 XP_011547175 XM_011548874 XP_011547176 XR_429034 XR_429035 XR_953254 XR_953255 NM_002336 NP_002327
|
| Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
|
| Top Pathways |
Wnt signaling pathway
|