LRP6

Gene Symbol LRP6
Entrez Gene 4040
Alt Symbol ADCAD2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 6
Other Description LRP-6|low-density lipoprotein receptor-related protein 6
Swissprots O75581 Q17RZ2
Accessions AAD21410 CCF76957 CDM49020 EAW96253 O75581 AA126261 AB209683 BAD92920 AF074264 AAC33006 AK074543 BAG51971 AK074902 BAG52027 AK094666 AK124760 BC029941 BC117136 AAI17137 BC126405 AAI26406 BC143725 AAI43726 BP229563 XM_006719078 XP_006719141 XM_011520671 XP_011518973 XM_011548873 XP_011547175 XM_011548874 XP_011547176 XR_429034 XR_429035 XR_953254 XR_953255 NM_002336 NP_002327
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}.
Tissue Specificity Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
Top Pathways Wnt signaling pathway

SignalSilence ® LRP6 siRNA II - 8623 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from 293 cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® LRP6 siRNA I #8650 (+) or SignalSilence ® LRP6 siRNA II (+), using LRP6 (C5C7) Rabbit mAb #2560 (upper) or α-Tubulin (11H10) Rabbit mAb #2125 (lower). The LRP6 (C5C7) Rabbit mAb confirms silencing of LRP6 expression, while the α-Tubulin (11H10) Rabbit mAb is used as a loading control.

SignalSilence ® LRP6 siRNA I - 8650 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Human
Western blot analysis of extracts from 293 cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® LRP6 siRNA I (+) or SignalSilence ® LRP6 siRNA II #8623 (+), using LRP6 (C5C7) Rabbit mAb #2560 (upper) or α-Tubulin (11H10) Rabbit mAb #2125 (lower). The LRP6 (C5C7) Rabbit mAb confirms silencing of LRP6 expression, while the α-Tubulin (11H10) Rabbit mAb is used as a loading control.

LRP6 CRISPR/Cas9 KO Plasmid (h) - sc-400844 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 HDR Plasmid (h) - sc-400844-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 Double Nickase Plasmid (h) - sc-400844-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 Double Nickase Plasmid (h2) - sc-400844-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 CRISPR Activation Plasmid (h) - sc-400844-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 CRISPR Activation Plasmid (h2) - sc-400844-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 Lentiviral Activation Particles (h) - sc-400844-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 Lentiviral Activation Particles (h2) - sc-400844-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 siRNA (h) - sc-37233 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP6 shRNA Plasmid (h) - sc-37233-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP6 shRNA (h) Lentiviral Particles - sc-37233-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP-6 RNAi - H00004040-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU027961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1273 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1273 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LRP6 siRNA (Human) - CRH2731 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Lrp6 (NM_002336.2) - SHH334071 from Creative biogene

Category siRNA
Species Reactivities Human

LRP6 CRISPR/Cas9 KO Plasmid (h2) - sc-400844-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 HDR Plasmid (h2) - sc-400844-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP6 shRNA Plasmid (Human) - CHH2731 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRP6 miRNA 3'UTR clone - MiUTR1H-05901 from Creative biogene

Species Reactivities Human
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