| Gene Symbol |
PLXNB1
|
| Entrez Gene |
5364
|
| Alt Symbol |
PLEXIN-B1, PLXN5, SEP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin B1
|
| Other Description |
plexin 5|plexin-B1|semaphorin receptor SEP
|
| Swissprots |
Q6NY20 Q9UJ92 Q9UIV7 A6H8Y2 Q9UJ93 O43157
|
| Accessions |
EAW64864 EAW64865 EAW64866 O43157 AB007867 BAA23703 AJ011414 CAB56221 AJ011415 CAB56222 AK091832 BAG52423 AK092609 BAG52582 AK296776 BAG59355 BC066773 BC128094 AAI28095 BC129947 BC146793 AAI46794 LN626690 CEH24705 X87904 CAB57277 XM_011533832 XP_011532134 XM_011533833 XP_011532135 XM_011533834 XP_011532136 XM_011533835 XP_011532137 XM_011533836 XP_011532138 XM_011533837 XP_011532139 XR_940457 XR_940458 NM_001130082 NP_001123554 NM_002673 NP_002664
|
| Function |
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.
|
| Subcellular Location |
Isoform 3: Secreted.
|
| Tissue Specificity |
Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: Plexin B1 Overexpression Lysate (Adult Normal) [NBP2-10842] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Plexin B1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9568_Plexin%2520B1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10842-img0001.jpg)