Gene Symbol | PLXNB1 |
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Entrez Gene | 5364 |
Alt Symbol | PLEXIN-B1, PLXN5, SEP |
Species | Human |
Gene Type | protein-coding |
Description | plexin B1 |
Other Description | plexin 5|plexin-B1|semaphorin receptor SEP |
Swissprots | Q6NY20 Q9UJ92 Q9UIV7 A6H8Y2 Q9UJ93 O43157 |
Accessions | EAW64864 EAW64865 EAW64866 O43157 AB007867 BAA23703 AJ011414 CAB56221 AJ011415 CAB56222 AK091832 BAG52423 AK092609 BAG52582 AK296776 BAG59355 BC066773 BC128094 AAI28095 BC129947 BC146793 AAI46794 LN626690 CEH24705 X87904 CAB57277 XM_011533832 XP_011532134 XM_011533833 XP_011532135 XM_011533834 XP_011532136 XM_011533835 XP_011532137 XM_011533836 XP_011532138 XM_011533837 XP_011532139 XR_940457 XR_940458 NM_001130082 NP_001123554 NM_002673 NP_002664 |
Function | Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
Subcellular Location | Isoform 3: Secreted. |
Tissue Specificity | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}. |
Top Pathways | Axon guidance |
plexin-B1 CRISPR/Cas9 KO Plasmid (h) - sc-401840 from Santa Cruz Biotechnology
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plexin-B1 HDR Plasmid (h) - sc-401840-HDR from Santa Cruz Biotechnology
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plexin-B1 Double Nickase Plasmid (h) - sc-401840-NIC from Santa Cruz Biotechnology
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plexin-B1 Double Nickase Plasmid (h2) - sc-401840-NIC-2 from Santa Cruz Biotechnology
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plexin-B1 CRISPR Activation Plasmid (h) - sc-401840-ACT from Santa Cruz Biotechnology
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plexin-B1 CRISPR Activation Plasmid (h2) - sc-401840-ACT-2 from Santa Cruz Biotechnology
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plexin-B1 Lentiviral Activation Particles (h) - sc-401840-LAC from Santa Cruz Biotechnology
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plexin-B1 Lentiviral Activation Particles (h2) - sc-401840-LAC-2 from Santa Cruz Biotechnology
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plexin-B1 siRNA (h) - sc-42176 from Santa Cruz Biotechnology
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plexin-B1 shRNA Plasmid (h) - sc-42176-SH from Santa Cruz Biotechnology
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plexin-B1 shRNA (h) Lentiviral Particles - sc-42176-V from Santa Cruz Biotechnology
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Plexin B1 RNAi - H00005364-R02 from Novus Biologicals
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MISSION® esiRNA - EHU114461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17013 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17013 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04886 from Sigma-Aldrich
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PLXNB1 siRNA (Human) - CRH3601 from Cohesion Biosciences
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shRNA set against Human PLXNB1 (NM_002673.4) - SHH378236 from Creative biogene
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Human PLXNB1 siRNA - orb264103 from Biorbyt
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PLXNB1 shRNA Plasmid (Human) - CHH3601 from Cohesion Biosciences
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PLXNB1 miRNA 3'UTR clone - MiUTR3H-03842 from Creative biogene
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PLXNB1 miRNA 3'UTR clone - MiUTR3H-03843 from Creative biogene
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