Gene Symbol | PLXNB1 |
---|---|
Entrez Gene | 5364 |
Alt Symbol | PLEXIN-B1, PLXN5, SEP |
Species | Human |
Gene Type | protein-coding |
Description | plexin B1 |
Other Description | plexin 5|plexin-B1|semaphorin receptor SEP |
Swissprots | Q6NY20 Q9UJ92 Q9UIV7 A6H8Y2 Q9UJ93 O43157 |
Accessions | EAW64864 EAW64865 EAW64866 O43157 AB007867 BAA23703 AJ011414 CAB56221 AJ011415 CAB56222 AK091832 BAG52423 AK092609 BAG52582 AK296776 BAG59355 BC066773 BC128094 AAI28095 BC129947 BC146793 AAI46794 LN626690 CEH24705 X87904 CAB57277 XM_011533832 XP_011532134 XM_011533833 XP_011532135 XM_011533834 XP_011532136 XM_011533835 XP_011532137 XM_011533836 XP_011532138 XM_011533837 XP_011532139 XR_940457 XR_940458 NM_001130082 NP_001123554 NM_002673 NP_002664 |
Function | Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
Subcellular Location | Isoform 3: Secreted. |
Tissue Specificity | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}. |
Top Pathways | Axon guidance |