| Gene Symbol | PELI2 |
|---|---|
| Entrez Gene | 57161 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | pellino E3 ubiquitin protein ligase family member 2 |
| Other Description | E3 ubiquitin-protein ligase pellino homolog 2|pellino homolog 2|pellino-2|protein pellino homolog 2 |
| Swissprots | B2RDY5 Q9HAT8 |
| Accessions | EAW80689 Q9HAT8 AF302502 AAG15390 AK025208 BAB15084 AK315727 BAG38082 AL133605 CAH56388 AL709755 BC009476 AAH09476 XM_005267890 XP_005267947 XM_006720211 XP_006720274 XM_011536990 XP_011535292 XM_011536991 XP_011535293 XM_011536992 XP_011535294 NM_021255 NP_067078 |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. {ECO:0000269|PubMed:12804775, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:22669975}. |
pellino homolog 2 (Drosophila) , ELISA Kit - MBS9340417 from MyBioSource
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Human PELI2 ELISA Kit - E028484 from Biobool
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