PELI2

Gene Symbol	PELI2
Entrez Gene	57161
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pellino E3 ubiquitin protein ligase family member 2
Other Description	E3 ubiquitin-protein ligase pellino homolog 2|pellino homolog 2|pellino-2|protein pellino homolog 2
Swissprots	B2RDY5 Q9HAT8
Accessions	EAW80689 Q9HAT8 AF302502 AAG15390 AK025208 BAB15084 AK315727 BAG38082 AL133605 CAH56388 AL709755 BC009476 AAH09476 XM_005267890 XP_005267947 XM_006720211 XP_006720274 XM_011536990 XP_011535292 XM_011536991 XP_011535293 XM_011536992 XP_011535294 NM_021255 NP_067078
Function	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. {ECO:0000269|PubMed:12804775, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:22669975}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PELI2 293T Cell Transient Overexpression Lysate(Denatured) - H00057161-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PELI2 293 Cell Lysate - 405952 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

Pellino 2 Overexpression Lysate (Native) - NBL1-14283 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PELI2 Over-expression Lysate Product - GWB-C401E1 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Pellino 2 Overexpression Lysate (Denatured) - H00057161-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human PELI2 Knockdown Stable Cell Line - CSC-DC011584 from Creative biogene Category Cell Line Species Human

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