| Gene Symbol |
PTGDR
|
| Entrez Gene |
5729
|
| Alt Symbol |
AS1, ASRT1, DP, DP1, PTGDR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin D2 receptor (DP)
|
| Other Description |
PGD2 receptor|prostaglandin D2 receptor
|
| Swissprots |
Q13250 Q1ZZ52 Q13251 G3V5L3 Q13258
|
| Accessions |
AAC50176 AAC50178 ABD72608 EAW65657 Q13258 AK026202 BC040968 AAH40968 CD013871 EF577397 ABQ52417 U31099 AAC50177 XM_005267891 XP_005267948 NM_000953 NP_000944 NM_001281469 NP_001268398
|
| Function |
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO:0000269|PubMed:11082108, ECO:0000269|PubMed:6302737}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|