Gene Symbol | PTGDR |
---|---|
Entrez Gene | 5729 |
Alt Symbol | AS1, ASRT1, DP, DP1, PTGDR1 |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin D2 receptor (DP) |
Other Description | PGD2 receptor|prostaglandin D2 receptor |
Swissprots | Q13250 Q1ZZ52 Q13251 G3V5L3 Q13258 |
Accessions | AAC50176 AAC50178 ABD72608 EAW65657 Q13258 AK026202 BC040968 AAH40968 CD013871 EF577397 ABQ52417 U31099 AAC50177 XM_005267891 XP_005267948 NM_000953 NP_000944 NM_001281469 NP_001268398 |
Function | Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO:0000269|PubMed:11082108, ECO:0000269|PubMed:6302737}. |
Top Pathways | Neuroactive ligand-receptor interaction |
DP CRISPR/Cas9 KO Plasmid (h) - sc-405497 from Santa Cruz Biotechnology
|
||||||||
DP HDR Plasmid (h) - sc-405497-HDR from Santa Cruz Biotechnology
|
||||||||
DP Double Nickase Plasmid (h) - sc-405497-NIC from Santa Cruz Biotechnology
|
||||||||
DP Double Nickase Plasmid (h2) - sc-405497-NIC-2 from Santa Cruz Biotechnology
|
||||||||
DP CRISPR Activation Plasmid (h) - sc-405497-ACT from Santa Cruz Biotechnology
|
||||||||
DP CRISPR Activation Plasmid (h2) - sc-405497-ACT-2 from Santa Cruz Biotechnology
|
||||||||
DP Lentiviral Activation Particles (h) - sc-405497-LAC from Santa Cruz Biotechnology
|
||||||||
DP Lentiviral Activation Particles (h2) - sc-405497-LAC-2 from Santa Cruz Biotechnology
|
||||||||
DP siRNA (h) - sc-62226 from Santa Cruz Biotechnology
|
||||||||
DP shRNA Plasmid (h) - sc-62226-SH from Santa Cruz Biotechnology
|
||||||||
DP shRNA (h) Lentiviral Particles - sc-62226-V from Santa Cruz Biotechnology
|
||||||||
PTGDR RNAi - H00005729-R02 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1848 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1848 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR10394 from Sigma-Aldrich
|
||||||||
PTGDR siRNA (Human) - CRH3873 from Cohesion Biosciences
|
||||||||
shRNA set against Human PTGDR (NM_000953.2) - SHH385944 from Creative biogene
|
||||||||
shRNA set against Human PTGDR(NM_000953.2) - SHG020077 from Creative biogene
|
||||||||
Human PTGDR siRNA - orb264375 from Biorbyt
|
||||||||
PTGDR shRNA Plasmid (Human) - CHH3873 from Cohesion Biosciences
|
||||||||
PTGDR miRNA 3'UTR clone - MiUTR1H-08414 from Creative biogene
|