GALNT2

Gene Symbol GALNT2
Entrez Gene 2590
Alt Symbol GalNAc-T2
Species Human
Gene Type protein-coding
Description polypeptide N-acetylgalactosaminyltransferase 2
Other Description UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)|polypeptide GalNAc transferase 2|pp-GaNTase 2
Swissprots A8K1Y3 Q9NPY4 B7Z8V8 Q10471 C5HU00
Accessions ACS13744 EAW69908 EAW69909 EAW69910 EAW69911 Q10471 AK025845 AK056187 AK097996 AK098468 AK290048 BAF82737 AK296886 BAH12448 AK300453 BAH13288 AK304029 BAH14094 BC041120 AAH41120 BC050583 BE328743 BF727269 BG773173 N53765 X85019 CAA59381 XM_011544154 XP_011542456 XM_011544155 XP_011542457 NM_001291866 NP_001278795 NM_004481 NP_004472 NR_120373
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. {ECO:0000269|PubMed:12438318, ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:7592619, ECO:0000269|PubMed:9295285}.
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Secreted {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:7592619}.
Top Pathways Mucin type O-Glycan biosynthesis

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