Gene Symbol | GALNT2 |
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Entrez Gene | 2590 |
Alt Symbol | GalNAc-T2 |
Species | Human |
Gene Type | protein-coding |
Description | polypeptide N-acetylgalactosaminyltransferase 2 |
Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)|polypeptide GalNAc transferase 2|pp-GaNTase 2 |
Swissprots | A8K1Y3 Q9NPY4 B7Z8V8 Q10471 C5HU00 |
Accessions | ACS13744 EAW69908 EAW69909 EAW69910 EAW69911 Q10471 AK025845 AK056187 AK097996 AK098468 AK290048 BAF82737 AK296886 BAH12448 AK300453 BAH13288 AK304029 BAH14094 BC041120 AAH41120 BC050583 BE328743 BF727269 BG773173 N53765 X85019 CAA59381 XM_011544154 XP_011542456 XM_011544155 XP_011542457 NM_001291866 NP_001278795 NM_004481 NP_004472 NR_120373 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. {ECO:0000269|PubMed:12438318, ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:7592619, ECO:0000269|PubMed:9295285}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Secreted {ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:7592619}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T2 CRISPR/Cas9 KO Plasmid (h) - sc-407708 from Santa Cruz Biotechnology
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GalNAc-T2 HDR Plasmid (h) - sc-407708-HDR from Santa Cruz Biotechnology
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GalNAc-T2 Double Nickase Plasmid (h) - sc-407708-NIC from Santa Cruz Biotechnology
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GalNAc-T2 Double Nickase Plasmid (h2) - sc-407708-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T2 CRISPR Activation Plasmid (h) - sc-407708-ACT from Santa Cruz Biotechnology
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GalNAc-T2 CRISPR Activation Plasmid (h2) - sc-407708-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T2 Lentiviral Activation Particles (h) - sc-407708-LAC from Santa Cruz Biotechnology
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GalNAc-T2 Lentiviral Activation Particles (h2) - sc-407708-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T2 siRNA (h) - sc-75094 from Santa Cruz Biotechnology
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GalNAc-T2 shRNA Plasmid (h) - sc-75094-SH from Santa Cruz Biotechnology
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GalNAc-T2 shRNA (h) Lentiviral Particles - sc-75094-V from Santa Cruz Biotechnology
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GALNT2 RNAi - H00002590-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9107 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9107 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11740 from Sigma-Aldrich
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GALNT2 siRNA (Human) - CRH1725 from Cohesion Biosciences
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GALNT2 - MBS8238458 from MyBioSource
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shRNA set against Human GALNT2 (NM_004481.3) - SHH299029 from Creative biogene
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GALNT2 shRNA Plasmid (Human) - CHH1725 from Cohesion Biosciences
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GALNT2 miRNA 3'UTR clone - MiUTR4H-TG03717 from Creative biogene
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