| Gene Symbol |
SLC1A5
|
| Entrez Gene |
6510
|
| Alt Symbol |
AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 1 (neutral amino acid transporter), member 5
|
| Other Description |
ATB(0)|RD114 virus receptor|RD114/simian type D retrovirus receptor|baboon M7 virus receptor|neutral amino acid transporter B|neutral amino acid transporter B(0)|sodium-dependent neutral amino acid transporter type 2|solute carrier family 1 member 5
|
| Swissprots |
Q15758 A8K9H5 Q9UNP2 B4DWS4 Q9BWQ3 O95720 E9PC01 B4DR77 B7ZB81 D0EYG6 Q96RL9
|
| Accessions |
EAW57446 Q15758 AB209738 BAD92975 AF102826 AAD09812 AF105230 AAD09814 AF105423 AAD27806 AF334818 AAK77026 AK055630 AK125222 AK292690 BAF85379 AK293433 BAG56938 AK299137 BAG61189 AK301661 BAG63136 AK316546 BAH14917 BC000062 AAH00062 DA031076 DQ892148 ABM83074 DQ895345 ABM86271 GQ919058 ACX53626 U53347 AAC50629 XM_005259167 XP_005259224 NM_001145144 NP_001138616 NM_001145145 NP_001138617 NM_005628 NP_005619
|
| Function |
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349). {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:23492904}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Tissue Specificity |
Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
|
| Top Pathways |
Protein digestion and absorption, Central carbon metabolism in cancer
|