SLC1A5

Gene Symbol SLC1A5
Entrez Gene 6510
Alt Symbol AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC
Species Human
Gene Type protein-coding
Description solute carrier family 1 (neutral amino acid transporter), member 5
Other Description ATB(0)|RD114 virus receptor|RD114/simian type D retrovirus receptor|baboon M7 virus receptor|neutral amino acid transporter B|neutral amino acid transporter B(0)|sodium-dependent neutral amino acid transporter type 2|solute carrier family 1 member 5
Swissprots Q15758 A8K9H5 Q9UNP2 B4DWS4 Q9BWQ3 O95720 E9PC01 B4DR77 B7ZB81 D0EYG6 Q96RL9
Accessions EAW57446 Q15758 AB209738 BAD92975 AF102826 AAD09812 AF105230 AAD09814 AF105423 AAD27806 AF334818 AAK77026 AK055630 AK125222 AK292690 BAF85379 AK293433 BAG56938 AK299137 BAG61189 AK301661 BAG63136 AK316546 BAH14917 BC000062 AAH00062 DA031076 DQ892148 ABM83074 DQ895345 ABM86271 GQ919058 ACX53626 U53347 AAC50629 XM_005259167 XP_005259224 NM_001145144 NP_001138616 NM_001145145 NP_001138617 NM_005628 NP_005619
Function Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349). {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:23492904}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
Top Pathways Protein digestion and absorption, Central carbon metabolism in cancer

ASCT2 (V501) Antibody - 5345 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells, untreated or treated with peptide N-glycosidase F (PNGase F), and untreated SW620 cells, using ASCT2 (V501) Antibody.

ASCT2 (G11) Antibody - 5100 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-29 cells, untreated or treated with peptide N-glycosidase F (PNGase F), and untreated SW620 and Jurkat cells using ASCT2 (G11) Antibody.

ASCT2 (D7C12) Rabbit mAb - 8057 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7C12
Western blot analysis of extracts from HT-29 cells, untreated or treated with peptide N-glycosidase F (PNGase F), and untreated SW620 cells using ASCT2 (D7C12) Rabbit mAb.

ASCT2 (H-52) - sc-99002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ASCT2 (H-52): sc-99002. Western blot analysis of ASCT2 expression in HEL 92.1.7 (A) and MCF7 (B) whole cell lysates.

ASCT2 (F-19) - sc-50698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ASCT2 (F-19): sc-50698. Western blot analysis of ASCT2 expression in MCF7 whole cell lysate.

ASCT2 (J-25) - sc-130963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ASCT2 (J-25): sc-130963. Western blot analysis of ASCT2 expression in Jurkat whole cell lysate.

Anti-SLC1A5 antibody - ab84903 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC1A5 antibody (ab84903) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SLC1A5 antibody - ab187692 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC1A5 antibody (ab187692) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-SLC1A5 antibody - ab187708 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1: Detection of Human SLC1A5 by Immunoprecipitation from 293T whole cell lysate (0.5 - 1 mg for IP, 20% of IP loaded), using ab187708 at 6 µg per reaction.Lane 2: Control IgG.Subsequent Western blot detection used an antibody whih recognised the C-terminal of Human SLC1A5 at 1 µg/ml.

Anti-SLC1A5 / ASCT2 Antibody (aa450-500) - LS-C290990 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ASCT2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-ASCT2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-SLC1A5 / ASCT2 Antibody (aa241-290) - LS-C31887 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SLC1A5 antibody LS-C31887 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SLC1A5 / ASCT2 Antibody (aa186-214) - LS-C161152 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SLC1A5 Antibody in K562 cell line lysates (35 ug/lane). SLC1A5 (arrow) was detected using the purified antibody.

Anti-SLC1A5 / ASCT2 Antibody (C-Terminus) IHC-plus™ - LS-A9774 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC1A5 antibody LS-A9774 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC1A5 / ASCT2 Antibody (Internal) IHC-plus™ - LS-A9044 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC1A5 antibody LS-A9044 IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC1A5 / ASCT2 Antibody (Internal) IHC-plus™ - LS-A9043 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC1A5 antibody LS-A9043 IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC1A5 / ASCT2 Antibody (Internal) IHC-plus™ - LS-A9042 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC1A5 antibody LS-A9042 IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC1A5 / ASCT2 Antibody (aa1-50) - LS-C290991 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC1A5 Antibody - NBP1-59732 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC1A5 Antibody [NBP1-59732] - Sample Tissue: Human 293T Antibody Dilution: 1.0 ug/ml

SLC1A5 Antibody - NBP1-89327 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SLC1A5 Antibody [NBP1-89327] - Staining of human cell line A-431 shows localization to plasma membrane.

SLC1A5 Antibody - NBP1-89328 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC1A5 Antibody - NBP2-32239 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC1A5 Antibody [NBP2-32239] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-SLC1A5 antibody NBP2-32239 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

SLC1A5 Antibody - NBP1-44240 from Novus Biologicals

Prices $369.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SLC1A5 Antibody [NBP1-44240] - Staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SLC1A5 Antibody - NBP2-32238 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC1A5 Polyclonal Antibody - bs-0473R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC1A5 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0473R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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