| Gene Symbol | C9 |
|---|---|
| Entrez Gene | 735 |
| Alt Symbol | ARMD15, C9D |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 9 |
| Other Description | complement component C9 |
| Swissprots | P02748 |
| Accessions | AAA51890 CAA69849 CAB66087 EAW55986 EAW55987 EAW55988 P02748 AK308045 BC020721 AAH20721 CB135741 CB157001 DQ891410 ABM82336 K02766 AAA51889 X02176 CAA26117 NM_001737 NP_001728 |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. |
| Subcellular Location | Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. |
| Tissue Specificity | Plasma. |
| Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis |