| Gene Symbol |
C9
|
| Entrez Gene |
735
|
| Alt Symbol |
ARMD15, C9D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 9
|
| Other Description |
complement component C9
|
| Swissprots |
P02748
|
| Accessions |
AAA51890 CAA69849 CAB66087 EAW55986 EAW55987 EAW55988 P02748 AK308045 BC020721 AAH20721 CB135741 CB157001 DQ891410 ABM82336 K02766 AAA51889 X02176 CAA26117 NM_001737 NP_001728
|
| Function |
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
|
| Subcellular Location |
Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
|
| Tissue Specificity |
Plasma.
|
| Top Pathways |
Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis
|