| Gene Symbol |
MFN1
|
| Entrez Gene |
55669
|
| Alt Symbol |
hfzo1, hfzo2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitofusin 1
|
| Other Description |
fzo homolog|mitochondrial transmembrane GTPase FZO-2|mitochondrial transmembrane GTPase Fzo-1|mitofusin-1|putative transmembrane GTPase|transmembrane GTPase MFN1
|
| Swissprots |
O15323 Q9NWQ2 Q9BZB5 Q8IWA4 D3DNR6 O60639 B2RAR1
|
| Accessions |
EAW78406 EAW78407 EAW78408 EAW78409 EAW78410 EAW78411 EAW78412 Q8IWA4 AB043588 BAE16564 AB043589 BAE16565 AF054986 AAC09347 AF329637 AAK06840 AI656503 AK000700 BAA91327 AK314306 BAG36958 BC020661 AAH20661 BC040557 AAH40557 CR627379 CAH10476 EU832493 ACE87665 EU832574 ACE86976 JF432789 ADZ16006 U95822 AAB64220 XM_005247596 XP_005247653 XM_011512963 XP_011511265 NM_033540 NP_284941 NM_017927
|
| Function |
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:23921378}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}; Multi- pass membrane protein {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}.
|
| Tissue Specificity |
Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. {ECO:0000269|PubMed:11751411, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.
|