MFN1

Gene Symbol MFN1
Entrez Gene 55669
Alt Symbol hfzo1, hfzo2
Species Human
Gene Type protein-coding
Description mitofusin 1
Other Description fzo homolog|mitochondrial transmembrane GTPase FZO-2|mitochondrial transmembrane GTPase Fzo-1|mitofusin-1|putative transmembrane GTPase|transmembrane GTPase MFN1
Swissprots O15323 Q9NWQ2 Q9BZB5 Q8IWA4 D3DNR6 O60639 B2RAR1
Accessions EAW78406 EAW78407 EAW78408 EAW78409 EAW78410 EAW78411 EAW78412 Q8IWA4 AB043588 BAE16564 AB043589 BAE16565 AF054986 AAC09347 AF329637 AAK06840 AI656503 AK000700 BAA91327 AK314306 BAG36958 BC020661 AAH20661 BC040557 AAH40557 CR627379 CAH10476 EU832493 ACE87665 EU832574 ACE86976 JF432789 ADZ16006 U95822 AAB64220 XM_005247596 XP_005247653 XM_011512963 XP_011511265 NM_033540 NP_284941 NM_017927
Function Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:23921378}.
Subcellular Location Mitochondrion outer membrane {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}; Multi- pass membrane protein {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}.
Tissue Specificity Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. {ECO:0000269|PubMed:11751411, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

Mitofusin-1 (D6E2S) Rabbit mAb - 14739 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6E2S
Western blot analysis of extracts from various cell lines using Mitofusin-1 (D6E2S) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Mitofusin-1 Antibody - 13196 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Mitofusin-1 Antibody.

Mfn1 (D-10) - sc-166644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mfn1 (D-10): sc-166644. Western blot analysis of Mfn1 expression in HeLa (A), Caki-1 (B), SK-MEL-28 (C), PC-3 (D), K-562 (E) and NIH/3T3 (F) whole cell lysates.

Mfn1 (C-19) - sc-30364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Mfn1 (H-65) - sc-50330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mfn1 (H-65): sc-50330. Western blot analysis of Mfn1 expression in non-transfected 293T: sc-117752 (A), mouse Mfn1 transfected 293T: sc-121621 (B) and HeLa (C) whole cell lysates.

Mfn1 (S-19) - sc-30363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mfn1 (S-19): sc-30363. Western blot analysis of Mfn1 expression in mouse brain tissue extract.

Anti-Mitofusin 1 antibody - ab57602 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-Mitofusin 1 antibody (ab57602) at 1/1000 dilutionLane 1 : Cynomolgus Monkey peripheral blood mononuclear whole cell lysateLane 2 : Cynomolgus Monkey peripheral blood mononuclear whole cell lysateLane 3 : Cynomolgus Monkey peripheral blood mononuclear whole cell lysateLane 4 : Cynomolgus Monkey peripheral blood mononuclear whole cell lysateLysates/proteins at 20 µg per lane.SecondaryHRP-conjugated Goat anti-mouse IgG polyclonal at 1/2000 dilutionPerformed under reducing conditions.

Anti-Mitofusin 1 antibody - ab104274 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab104274 staining Mitofusin 1 in the H9C2 cell line from Rat heart by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Triton X-100 1%  and blocked with 5% Serum for 60 minutes at 21°C. Samples were incubated with primary antibody (1/200 in PBS + 5% Goat serum) for 2 hours at 21°C. AnAlexa Fluor®488-conjugated Goat anti-rabbit IgG polyclonal (1/400) was used as the secondary antibody.See Abreview

Anti-Mitofusin 1 antibody - ab107129 from Abcam

Prices $384.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
ICC/IF image of ab107129 stained DU145 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab107129 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- chicken (ab96947) IgY (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Mitofusin 1 antibody - ab104585 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Mitofusin 1 antibody - ab94508 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mitofusin 1 antibody (ab94508) at 1 µg/mlLane 1 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell LysateLane 2 : MEF1 (Mouse embryonic fibroblast cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Mitofusin 1 antibody - ab123641 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Mitofusin 1 antibody (ab123641) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-Mitofusin 1 antibody - ab111271 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111271, at 3.75µg/ml, staining Mitofusin 1 in formalin-fixed, paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

Anti-Mitofusin 1 antibody [4D11] - ab170554 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D11
Immunohistochemical analysis of formalin fixed/ paraffin embedded Human prostate tissue labeling Mitofusin 1 with ab170554 at a 1/150 dilution.

Anti-Mitofusin 1 antibody [EPR7960] - ab129154 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7960
All lanes : Anti-Mitofusin 1 antibody [EPR7960] (ab129154) at 1/10000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : PC3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Mitofusin 1 antibody - N-terminal - ab191853 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Mitofusin 1 antibody - N-terminal (ab191853) at 1 µg/ml + A431 cell lysate at 15 µgdeveloped using the ECL technique

Anti-MFN1 Antibody (N-Terminus) IHC-plus™ - LS-B12149 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-MFN1 Antibody (aa745-756) IHC-plus™ - LS-B3816 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MFN1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3816 concentration 3.75 ug/ml.

Anti-MFN1 Antibody (aa5-100, DY650) - LS-C143575 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MFN1 Antibody (aa5-100, Biotin) - LS-C143574 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MFN1 Antibody (aa5-100, DY488) - LS-C143576 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MFN1 Antibody (aa5-100, HRP) - LS-C143577 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MFN1 Antibody (aa5-100, DY550) - LS-C143578 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MFN1 Antibody (C-Terminus) - LS-C116739 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MFN1 antibody LS-C116739 Western blot of Placenta lysate.

Anti-MFN1 Antibody (clone 11E9-1H12, Biotin) - LS-C180682 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11E9-1H12
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