MFN1

Gene Symbol	MFN1
Entrez Gene	55669
Alt Symbol	hfzo1, hfzo2
Species	Human
Gene Type	protein-coding
Description	mitofusin 1
Other Description	fzo homolog|mitochondrial transmembrane GTPase FZO-2|mitochondrial transmembrane GTPase Fzo-1|mitofusin-1|putative transmembrane GTPase|transmembrane GTPase MFN1
Swissprots	O15323 Q9NWQ2 Q9BZB5 Q8IWA4 D3DNR6 O60639 B2RAR1
Accessions	EAW78406 EAW78407 EAW78408 EAW78409 EAW78410 EAW78411 EAW78412 Q8IWA4 AB043588 BAE16564 AB043589 BAE16565 AF054986 AAC09347 AF329637 AAK06840 AI656503 AK000700 BAA91327 AK314306 BAG36958 BC020661 AAH20661 BC040557 AAH40557 CR627379 CAH10476 EU832493 ACE87665 EU832574 ACE86976 JF432789 ADZ16006 U95822 AAB64220 XM_005247596 XP_005247653 XM_011512963 XP_011511265 NM_033540 NP_284941 NM_017927
Function	Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:23921378}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}; Multi- pass membrane protein {ECO:0000305|PubMed:11751411, ECO:0000305|PubMed:12759376}.
Tissue Specificity	Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. {ECO:0000269|PubMed:11751411, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Mitofusin-1 siRNA II - 13303 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Mitofusin-1 siRNA I - 13274 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Mfn1 CRISPR/Cas9 KO Plasmid (h) - sc-400637 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 HDR Plasmid (h) - sc-400637-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 Double Nickase Plasmid (h) - sc-400637-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 Double Nickase Plasmid (h2) - sc-400637-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 CRISPR Activation Plasmid (h) - sc-400637-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 CRISPR Activation Plasmid (h2) - sc-400637-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 Lentiviral Activation Particles (h) - sc-400637-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 Lentiviral Activation Particles (h2) - sc-400637-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn1 siRNA (h) - sc-43927 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mfn1 shRNA Plasmid (h) - sc-43927-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mfn1 shRNA (h) Lentiviral Particles - sc-43927-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mitofusin 1 RNAi - H00055669-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Mitofusin 1 RNAi - H00055669-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113211 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13254 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13254 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MFN1 siRNA (Human) - CRJ0821 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Mitofusin 1 RNAi - H00055669-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MFN1 (NM_033540.2) - SHH341103 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MFN1(NM_033540.2) - SHH186635 from Creative biogene Category siRNA Species Reactivities Human

Human MFN1 siRNA - orb271322 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MFN1 shRNA Plasmid (Human) - CHJ0821 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MFN1 miRNA 3'UTR clone - MiUTR1H-06239 from Creative biogene Species Reactivities Human

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