| Gene Symbol |
Rnf6
|
| Entrez Gene |
74132
|
| Alt Symbol |
1200013I08Rik, 5730419H05Rik, AA537053
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein (C3H2C3 type) 6
|
| Other Description |
E3 ubiquitin-protein ligase RNF6|RLIM-like protein
|
| Swissprots |
B2RRR0 Q8K565 Q9DBU5
|
| Accessions |
EDL05800 EDL05801 EDL05802 Q9DBU5 AK004745 BAB23526 AK017576 AK029912 AK049503 AK150269 BAE29425 AK152106 BAE30953 AV586321 AY039004 AAK84435 BC138545 AAI38546 BY136428 BY323318 CX237430 XM_011241015 XP_011239317 NM_001256085 NP_001243014 NM_001256086 NP_001243015 NM_001256087 NP_001243016 NM_028774 NP_083050
|
| Function |
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:11971979, ECO:0000269|PubMed:16204183}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.
|
| Tissue Specificity |
Widely expressed with higher expression in the testis in both germ cells and Sertoli cells. {ECO:0000269|PubMed:11971979}.
|