Gene Symbol | Rnf6 |
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Entrez Gene | 74132 |
Alt Symbol | 1200013I08Rik, 5730419H05Rik, AA537053 |
Species | Mouse |
Gene Type | protein-coding |
Description | ring finger protein (C3H2C3 type) 6 |
Other Description | E3 ubiquitin-protein ligase RNF6|RLIM-like protein |
Swissprots | B2RRR0 Q8K565 Q9DBU5 |
Accessions | EDL05800 EDL05801 EDL05802 Q9DBU5 AK004745 BAB23526 AK017576 AK029912 AK049503 AK150269 BAE29425 AK152106 BAE30953 AV586321 AY039004 AAK84435 BC138545 AAI38546 BY136428 BY323318 CX237430 XM_011241015 XP_011239317 NM_001256085 NP_001243014 NM_001256086 NP_001243015 NM_001256087 NP_001243016 NM_028774 NP_083050 |
Function | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:11971979, ECO:0000269|PubMed:16204183}. |
Subcellular Location | Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells. |
Tissue Specificity | Widely expressed with higher expression in the testis in both germ cells and Sertoli cells. {ECO:0000269|PubMed:11971979}. |
RNF6 Antibody - NBP1-80251 from Novus Biologicals
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Anti-RNF6 antibody produced in rabbit - AV37397 from Sigma-Aldrich
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RNF6 antibody - N-terminal region (ARP37397_T100) - ARP37397_T100 from Aviva Systems Biology
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RNF6 antibody - 20R-1156 from Fitzgerald
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Ring Finger Protein (C3H2C3 Type) 6 Antibody - abx115286 from Abbexa
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RNF6 Antibody - 28-667 from ProSci
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RNF6 Antibody - GWB-E12BCE from Genway Biotech
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RNF6, Polyclonal Antibody - MBS833977 from MyBioSource
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RNF6 Antibody - CSB-PA019896GA01HU from Cusabio
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RNF6 antibody - TA329953 from Acris Antibodies
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RNF6 antibody - N-terminal region : Biotin (ARP37397_T100-Biotin) - ARP37397_T100-Biotin from Aviva Systems Biology
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RNF6 antibody - N-terminal region : FITC (ARP37397_T100-FITC) - ARP37397_T100-FITC from Aviva Systems Biology
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RNF6 antibody - N-terminal region : HRP (ARP37397_T100-HRP) - ARP37397_T100-HRP from Aviva Systems Biology
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Anti-RNF6 Antibody A09820 - A09820 from Boster Bio
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