KLHL3

Gene Symbol KLHL3
Entrez Gene 26249
Alt Symbol PHA2D
Species Human
Gene Type protein-coding
Description kelch-like family member 3
Other Description kelch-like protein 3
Swissprots Q9ULU0 Q9UH75 Q9UH76 B2RBK7 Q9Y6V6 Q9UH77
Accessions AAB97127 EAW62183 EAW62184 Q9UH77 AB032955 BAA86443 AF208068 AAF20938 AF208069 AAF20939 AF208070 AAF20995 AK300172 BAH13228 AK303916 BAH14080 AK310568 AK311594 AK314707 BAG37254 BC034035 AAH34035 BC045683 AAH45683 DA083147 NM_001257194 NP_001244123 NM_001257195 NP_001244124 NM_017415 NP_059111
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:22406640, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:23665031}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22406640}. Cytoplasm, cytosol {ECO:0000269|PubMed:22406640}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:22406640}.

KLHL3 (K-24) - sc-133714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
KLHL3 (K-24): sc-133714. Western blot analysis of KLHL3 expression in Hep G2 whole cell lysate.

Anti-KLHL3 antibody - ab153838 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KLHL3 antibody (ab153838) at 1/10000 dilution + A549 whole cell lysate at 30 µg

Anti-KLHL3 antibody - ab86390 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KLHL3 antibody (ab86390) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KLHL3 antibody - ab66655 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KLHL3 antibody (ab66655) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KLHL3 antibody - ab130471 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KLHL3 antibody (ab130471) at 1/100 dilution + HL60 cell line lysates at 35 µg

Anti-KLHL3 antibody - N-terminal - ab196776 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KLHL3 antibody - N-terminal (ab196776) at 1/500 dilutionLane 1 : RAW264.7 cell extractLane 2 : 3T3 cell extractLane 3 : 3T3 cell extract with synthesized peptide

Anti-KLHL3 Antibody (aa71-120) IHC-plus™ - LS-B5609 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KLHL3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5609 concentration 5 ug/ml.

Anti-KLHL3 Antibody (aa206-234, Biotin) - LS-C236889 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (aa206-234, APC) - LS-C236888 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (aa206-234, FITC) - LS-C236890 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (N-Terminus) - LS-C31304 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-KLHL3 Antibody (aa206-234, PE) - LS-C236891 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (aa206-234, Azide-free, HRP) - LS-C248660 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (aa206-234, AP) - LS-C249992 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (aa14-63) - LS-C292124 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody (C-Terminus) - LS-C101743 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KLHL3 antibody LS-C101743 Western blot of HepG2 cell lysate.

Anti-KLHL3 Antibody (aa206-234) - LS-C322524 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLHL3 Antibody - LS-C308666 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-KLHL3 Antibody (aa10-59) - LS-C199173 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using KLHL3 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-KLHL3 Antibody (aa149-198) - LS-C201298 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Breast Tumor. KLHL3 antibody dilution 1.0 ug/ml.

Anti-KLHL3 Antibody (aa207-234) - LS-C165574 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KLHL3 Antibody western blot of HL-60 cell line lysates (35 ug/lane). The KLHL3 antibody detected the KLHL3 protein (arrow).

Kelch-Like 3 Antibody - NBP2-14168 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kelch-Like 3 Antibody [NBP2-14168] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

Kelch-Like 3 Antibody - NBP2-17037 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kelch-Like 3 Antibody [NBP2-17037] - Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE gel, diluted at 1:10000.

Kelch-Like 3 Antibody - H00026249-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Kelch-Like 3 Antibody [H00026249-B01P] - Analysis of KLHL3 expression in transfected 293T cell line by KLHL3 polyclonal antibody. Lane 1: KLHL3 transfected lysate(33.11 KDa). Lane 2: Non-transfected lysate.

Kelch-Like 3 Antibody - H00026249-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Kelch-Like 3 Antibody [H00026249-B01] - analysis of KLHL3 expression in transfected 293T cell line by KLHL3 MaxPab polyclonal antibody (B01). Lane 1: KLHL3 transfected lysate (34.10 KDa). Lane 2: Non-transfected lysate.
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