KLHL3

Gene Symbol KLHL3
Entrez Gene 26249
Alt Symbol PHA2D
Species Human
Gene Type protein-coding
Description kelch-like family member 3
Other Description kelch-like protein 3
Swissprots Q9ULU0 Q9UH75 Q9UH76 B2RBK7 Q9Y6V6 Q9UH77
Accessions AAB97127 EAW62183 EAW62184 Q9UH77 AB032955 BAA86443 AF208068 AAF20938 AF208069 AAF20939 AF208070 AAF20995 AK300172 BAH13228 AK303916 BAH14080 AK310568 AK311594 AK314707 BAG37254 BC034035 AAH34035 BC045683 AAH45683 DA083147 NM_001257194 NP_001244123 NM_001257195 NP_001244124 NM_017415 NP_059111
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:22406640, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:23665031}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22406640}. Cytoplasm, cytosol {ECO:0000269|PubMed:22406640}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:22406640}.

KLHL3 CRISPR/Cas9 KO Plasmid (h) - sc-409880 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 HDR Plasmid (h) - sc-409880-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 Double Nickase Plasmid (h) - sc-409880-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 Double Nickase Plasmid (h2) - sc-409880-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 CRISPR Activation Plasmid (h) - sc-409880-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 CRISPR Activation Plasmid (h2) - sc-409880-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 Lentiviral Activation Particles (h) - sc-409880-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 Lentiviral Activation Particles (h2) - sc-409880-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL3 siRNA (h) - sc-91638 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KLHL3 shRNA Plasmid (h) - sc-91638-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KLHL3 shRNA (h) Lentiviral Particles - sc-91638-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Kelch-Like 3 RNAi - H00026249-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11288 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11288 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KLHL3 siRNA (Human) - CRH8777 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KLHL3 (NM_017415.2) - SHH326255 from Creative biogene

Category siRNA
Species Reactivities Human

KLHL3 shRNA Plasmid (Human) - CHH8777 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KLHL3 miRNA 3'UTR clone - MiUTR1H-05377 from Creative biogene

Species Reactivities Human
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