| Gene Symbol |
KLHL3
|
| Entrez Gene |
26249
|
| Alt Symbol |
PHA2D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 3
|
| Other Description |
kelch-like protein 3
|
| Swissprots |
Q9ULU0 Q9UH75 Q9UH76 B2RBK7 Q9Y6V6 Q9UH77
|
| Accessions |
AAB97127 EAW62183 EAW62184 Q9UH77 AB032955 BAA86443 AF208068 AAF20938 AF208069 AAF20939 AF208070 AAF20995 AK300172 BAH13228 AK303916 BAH14080 AK310568 AK311594 AK314707 BAG37254 BC034035 AAH34035 BC045683 AAH45683 DA083147 NM_001257194 NP_001244123 NM_001257195 NP_001244124 NM_017415 NP_059111
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:22406640, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:23665031}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22406640}. Cytoplasm, cytosol {ECO:0000269|PubMed:22406640}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:22406640}.
|