| Gene Symbol |
KPNA5
|
| Entrez Gene |
3841
|
| Alt Symbol |
IPOA6, SRP6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
karyopherin alpha 5 (importin alpha 6)
|
| Other Description |
importin alpha 6|importin subunit alpha-6|karyopherin subunit alpha-5
|
| Swissprots |
Q86X23 B2RAI5 O15131
|
| Accessions |
EAW48216 O15131 AA332147 AF005361 AAC51868 AK314206 BAG36882 BC047409 AAH47409 BG721781 HQ447973 ADQ32456 XM_011535805 XP_011534107 XM_011535806 XP_011534108 XM_011535807 XP_011534109 NM_002269 NP_002260
|
| Function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influe
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Testis.
|
![Western Blot: KPNA5 Overexpression Lysate (Adult Normal) [NBL1-12373] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KPNA5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3443_KPNA5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12373-img0002.jpg)