KPNA5
| Gene Symbol | KPNA5 |
|---|---|
| Entrez Gene | 3841 |
| Alt Symbol | IPOA6, SRP6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin alpha 5 (importin alpha 6) |
| Other Description | importin alpha 6|importin subunit alpha-6|karyopherin subunit alpha-5 |
| Swissprots | Q86X23 B2RAI5 O15131 |
| Accessions | EAW48216 O15131 AA332147 AF005361 AAC51868 AK314206 BAG36882 BC047409 AAH47409 BG721781 HQ447973 ADQ32456 XM_011535805 XP_011534107 XM_011535806 XP_011534108 XM_011535807 XP_011534109 NM_002269 NP_002260 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influe |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Testis. |
karyopherin α5 (D-19) - sc-68194 from Santa Cruz Biotechnology
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karyopherin α5 (N-20) - sc-68195 from Santa Cruz Biotechnology
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Anti-KPNA5 antibody - ab125529 from Abcam
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Anti-KPNA5 antibody - ab154387 from Abcam
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Anti-KPNA5 antibody - ab81450 from Abcam
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Anti-KPNA5 antibody - ab55389 from Abcam
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Anti-KPNA5 antibody - ab113802 from Abcam
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Anti-KPNA5 antibody - N-terminal - ab189987 from Abcam
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Anti-KPNA5 antibody - N-terminal - ab138938 from Abcam
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Anti-KPNA5 Antibody (aa434-483) - LS-C81903 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, AP) - LS-C261521 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, APC) - LS-C261522 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, Biotin) - LS-C261523 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, FITC) - LS-C261524 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, Azide-free, HRP) - LS-C261526 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30) - LS-C160017 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30, PE) - LS-C261527 from LifeSpan Bioscience
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Anti-KPNA5 Antibody - LS-C310841 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-30) - LS-C322541 from LifeSpan Bioscience
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Anti-KPNA5 Antibody - LS-C310842 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (aa1-540, Azide-free) - LS-C327697 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (N-Terminus) IHC-plus⢠- LS-B4728 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (clone 1D2) - LS-C197583 from LifeSpan Bioscience
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Anti-KPNA5 Antibody (N-Terminus) IHC-plus⢠- LS-B9592 from LifeSpan Bioscience
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KPNA5 Antibody - NBP1-52978 from Novus Biologicals
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