KPNA5

Gene Symbol	KPNA5
Entrez Gene	3841
Alt Symbol	IPOA6, SRP6
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 5 (importin alpha 6)
Other Description	importin alpha 6|importin subunit alpha-6|karyopherin subunit alpha-5
Swissprots	Q86X23 B2RAI5 O15131
Accessions	EAW48216 O15131 AA332147 AF005361 AAC51868 AK314206 BAG36882 BC047409 AAH47409 BG721781 HQ447973 ADQ32456 XM_011535805 XP_011534107 XM_011535806 XP_011534108 XM_011535807 XP_011534109 NM_002269 NP_002260
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influe
Subcellular Location	Cytoplasm.
Tissue Specificity	Testis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

karyopherin α5 CRISPR/Cas9 KO Plasmid (h) - sc-416486 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 HDR Plasmid (h) - sc-416486-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 Double Nickase Plasmid (h) - sc-416486-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 Double Nickase Plasmid (h2) - sc-416486-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 CRISPR Activation Plasmid (h) - sc-416486-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 CRISPR Activation Plasmid (h2) - sc-416486-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 Lentiviral Activation Particles (h) - sc-416486-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 Lentiviral Activation Particles (h2) - sc-416486-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

karyopherin α5 siRNA (h) - sc-62523 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

karyopherin α5 shRNA Plasmid (h) - sc-62523-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

karyopherin α5 shRNA (h) Lentiviral Particles - sc-62523-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KPNA5 RNAi - H00003841-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

KPNA5 RNAi - H00003841-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU016871 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11341 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11341 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02906 from Sigma-Aldrich Category miRNA

KPNA5 siRNA (Human) - CRH2604 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human KPNA5 (NM_002269.2) - SHH327035 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KPNA5(NM_002269.2) - SHL204366 from Creative biogene Category siRNA Species Reactivities Human

Human KPNA5 siRNA - orb263106 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KPNA5 shRNA Plasmid (Human) - CHH2604 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KPNA5 miRNA 3'UTR clone - MiUTR1H-05425 from Creative biogene Species Reactivities Human

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