CHIA

Gene Symbol	CHIA
Entrez Gene	27159
Alt Symbol	AMCASE, CHIT2, TSA1902
Species	Human
Gene Type	protein-coding
Description	chitinase, acidic
Other Description	acidic mammalian chitinase|lung-specific protein TSA1902
Swissprots	Q3B866 Q5VUV4 Q32W80 Q9BZP6 Q32W79 Q5U5Z5 Q86UD8 Q9ULY3 Q9ULY4
Accessions	EAW56485 EAW56486 EAW56487 EAW56488 Q9BZP6 AB025008 BAA86980 AB025009 BAA86981 AF290004 AAG60019 AK098814 AK290702 BAF83391 AY789444 AAX81431 AY789445 AAX81432 AY825504 AAX54833 AY911310 AAX81433 AY911311 AAX81434 BC036339 AAH36339 BC047336 AAH47336 BC106910 AAI06911 BC139901 AAI39902 BC139920 AAI39921 XM_006710577 XP_006710640 NM_001040623 NP_001035713 NM_001258001 NP_001244930 NM_001258002 NP_001244931 NM_001258003 NP_001244932 NM_001258004 NP_001244933 NM_001258005 NP_001244934 NM_021797 NP_068569 NM_201653 NP_970615
Function	Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19342690, ECO:0000269|PubMed:19435888}.
Subcellular Location	Isoform 3: Cytoplasm.
Tissue Specificity	Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:15192232}.
Top Pathways	Amino sugar and nucleotide sugar metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHIA full length protein - ab132796 from Abcam Category Protein Source Wheat germ Species Human

Human CHIA peptide - ab91083 from Abcam Category Peptide

CHIA / Amcase Antibody Blocking Peptide - LS-E15687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHIA / Amcase Antibody Blocking Peptide - LS-E15688 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHIA / Amcase Antibody Blocking Peptide - LS-E10106 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHIA Recombinant Protein - H00027159-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CHIA-Antibody-N-term-Blocking-Peptide - BP9394a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHIA Blocking Peptide - 33R-6610 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHIA Blocking Peptide - 33R-3598 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AMCase - H00027159-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AMCase - H00027159-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CHIA fusion protein - Ag15767 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CHIA fusion protein - ag15588 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CHIA, His-tagged - CHIA-11175H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Acidic mammalian chitinase(CHIA) - CSB-YP874858HU CSB-EP874858HU CSB-BP874858HU CSB-MP874858HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Acidic mammalian chitinase(CHIA) - MBS1376934 from MyBioSource Category Protein Prices $2,010.00, $2,010.00, $2,470.00, $2,470.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

AMCase (N-term HIS tag, transcript variant 2) - TP760630 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

CHIA Recombinant Protein Antigen - NBP2-32440PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHIA Peptide, Human - M34GP03090H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human CHIA protein - orb54413 from Biorbyt Category Protein Prices $213.00, $374.00, $553.00, $612.00, $1,020.00, $1,607.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

CHIA Recombinant Protein (Human) (OPCA04900) - OPCA04900 from Aviva Systems Biology Category Protein Species Human

Recombinant Human Acidic mammalian chitinase (CHIA) - RPC23632 from Biomatik Category Protein Prices $187.00, $342.00, $1,692.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

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