CHIA

Gene Symbol	CHIA
Entrez Gene	27159
Alt Symbol	AMCASE, CHIT2, TSA1902
Species	Human
Gene Type	protein-coding
Description	chitinase, acidic
Other Description	acidic mammalian chitinase|lung-specific protein TSA1902
Swissprots	Q3B866 Q5VUV4 Q32W80 Q9BZP6 Q32W79 Q5U5Z5 Q86UD8 Q9ULY3 Q9ULY4
Accessions	EAW56485 EAW56486 EAW56487 EAW56488 Q9BZP6 AB025008 BAA86980 AB025009 BAA86981 AF290004 AAG60019 AK098814 AK290702 BAF83391 AY789444 AAX81431 AY789445 AAX81432 AY825504 AAX54833 AY911310 AAX81433 AY911311 AAX81434 BC036339 AAH36339 BC047336 AAH47336 BC106910 AAI06911 BC139901 AAI39902 BC139920 AAI39921 XM_006710577 XP_006710640 NM_001040623 NP_001035713 NM_001258001 NP_001244930 NM_001258002 NP_001244931 NM_001258003 NP_001244932 NM_001258004 NP_001244933 NM_001258005 NP_001244934 NM_021797 NP_068569 NM_201653 NP_970615
Function	Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19342690, ECO:0000269|PubMed:19435888}.
Subcellular Location	Isoform 3: Cytoplasm.
Tissue Specificity	Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:15192232}.
Top Pathways	Amino sugar and nucleotide sugar metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AMCase (E-11) - sc-365676 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

AMCase (H-47) - sc-99060 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

AMCase (Q-16) - sc-49356 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AMCase (Y-14) - sc-49357 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CHIA antibody - ab72309 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHIA antibody - ab87078 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHIA antibody - ab83187 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHIA antibody - ab69409 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, AP) - LS-C233789 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, APC) - LS-C233788 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, Biotin) - LS-C233790 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, FITC) - LS-C233791 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, PE) - LS-C233792 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody - LS-C306939 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHIA / Amcase Antibody - LS-C309899 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus) - LS-C320352 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus, Azide-free, HRP) - LS-C249665 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (N-Terminus) - LS-C110704 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody (aa108-157) - LS-C101980 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody - LS-C332555 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody - LS-C334794 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CHIA / Amcase Antibody - LS-C168732 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CHIA Antibody - NBP2-32440 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHIA Antibody - NBP1-58988 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

CHIA Antibody - NBP1-58987 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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