CHIA

Gene Symbol CHIA
Entrez Gene 27159
Alt Symbol AMCASE, CHIT2, TSA1902
Species Human
Gene Type protein-coding
Description chitinase, acidic
Other Description acidic mammalian chitinase|lung-specific protein TSA1902
Swissprots Q3B866 Q5VUV4 Q32W80 Q9BZP6 Q32W79 Q5U5Z5 Q86UD8 Q9ULY3 Q9ULY4
Accessions EAW56485 EAW56486 EAW56487 EAW56488 Q9BZP6 AB025008 BAA86980 AB025009 BAA86981 AF290004 AAG60019 AK098814 AK290702 BAF83391 AY789444 AAX81431 AY789445 AAX81432 AY825504 AAX54833 AY911310 AAX81433 AY911311 AAX81434 BC036339 AAH36339 BC047336 AAH47336 BC106910 AAI06911 BC139901 AAI39902 BC139920 AAI39921 XM_006710577 XP_006710640 NM_001040623 NP_001035713 NM_001258001 NP_001244930 NM_001258002 NP_001244931 NM_001258003 NP_001244932 NM_001258004 NP_001244933 NM_001258005 NP_001244934 NM_021797 NP_068569 NM_201653 NP_970615
Function Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19342690, ECO:0000269|PubMed:19435888}.
Subcellular Location Isoform 3: Cytoplasm.
Tissue Specificity Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:15192232}.
Top Pathways Amino sugar and nucleotide sugar metabolism

AMCase CRISPR/Cas9 KO Plasmid (h) - sc-416496 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase HDR Plasmid (h) - sc-416496-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase Double Nickase Plasmid (h) - sc-416496-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase Double Nickase Plasmid (h2) - sc-416496-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase CRISPR Activation Plasmid (h) - sc-416496-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase CRISPR Activation Plasmid (h2) - sc-416496-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase Lentiviral Activation Particles (h) - sc-416496-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase Lentiviral Activation Particles (h2) - sc-416496-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AMCase siRNA (h) - sc-60160 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AMCase shRNA Plasmid (h) - sc-60160-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AMCase shRNA (h) Lentiviral Particles - sc-60160-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU147401 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6057 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6057 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHIA siRNA (Human) - CRH9001 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHIA - MBS8239581 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CHIA (NM_201653.3) - SHH263049 from Creative biogene

Category siRNA
Species Reactivities Human

Human CHIA siRNA - orb269503 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHIA shRNA Plasmid (Human) - CHH9001 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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