| Gene Symbol |
NOXA1
|
| Entrez Gene |
10811
|
| Alt Symbol |
NY-CO-31, SDCCAG31, p51NOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NADPH oxidase activator 1
|
| Other Description |
NCF2-like protein|Nox activator 1|antigen NY-CO-31|inhibitory NADPH oxidase activator 1|p51-nox|p67phox-like factor|serologically defined colon cancer antigen 31
|
| Swissprots |
Q8IUS3 Q29VV0 Q29VU9 O60533 Q86UR1 Q2TAM1
|
| Accessions |
Q86UR1 AB095031 BAC76710 AF039697 AAC18046 AI860821 AK055812 AK098341 AY255769 AAP13480 AY927790 AAY16126 AY927791 AAY16127 BC041594 AAH41594 BC110840 AAI10841 XM_011518158 XP_011516460 XM_011518159 XP_011516461 XM_011518160 XP_011516462 NM_001256067 NP_001242996 NM_001256068 NP_001242997 NM_006647 NP_006638
|
| Function |
Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
|
| Tissue Specificity |
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:12716910}.
|
![Western Blot: NOXA1 Overexpression Lysate (Adult Normal) [NBL1-13734] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NOXA1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8594_NOXA1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13734-img0002.jpg)